金属促进的有机化学反应

1 Heterocycle Synthesis through Direct Coupling of Aromatic and Vinylic C-H Bonds

1.1 Introduction

1.2 Construction of carbazoles

1.2.1 Tandem C H functionalization and C N bond formation

1.2.2 Pd （OAc）2 catalyzed oxidative biaryl synthesis

1.3 Construction of benzoxazoles

1.4 Construction of benzimidazoles

1.5 Construction of 2 substituted benzothiazoles

1.6 Construction of 3 aryl/alkylindazoles

1.7 Construction of indoles

1.8 Construction of indole derivatives oxindoles and indolines

1.8.1 Construction of oxindoles

1.8.2 Construction of indolines

1.9 Construction of benzolactams and phthalimides

1.10 Construction of dibenzofurans

1.11 Construction of brigehead unsaturated bicyclic enamines

1.12 Conclusion

References

2 Heterocycle Synthesis through Direct Coupling of Saturated C-H Bonds

2.1 Introduction

2.2 Intramolecular cyclization

2.2.1 C C bond formation

2.2.2 C N bond formation

2.2.3 C O bond formation

2.3 Intermolecular cyclization

2.3.1 Cyclization with insertion of alkenes

2.3.2 Cyclization with insertion of CO

2.3.3 Cyclization with insertion of alkynes

2.4 Conclusions

References

3 Direct Coupling of Aromatic C-H Bonds with a Nitrogen Atom

3.1 Introduction

3.2 C N bond formation of arenes having directing groups

3.2.1 Copper catalyzed/mediated C N bond formation

3.2.2 Palladium catalyzed C N bond formation

3.3 Copper（Ⅱ） acetate catalyzed/mediated C N bond formation of polyfluoro（chloro）arenes

3.4 Metal free C N bond formation of alkyl substituted arenes

3.5 Conclusion

References

4 Direct Coupling of Azole C-H Bonds with Nitrogen Groups

4.1 Introduction

4.2 Copper catalyzed/mediated amination

4.3 Acid promoted amination

4.4 Metal free amination

4.5 Conclusion

References

5 Copper-Promoted Direct sp2C-H Bond Transformation

5.1 Introduction

5.2 Aromatic ring C H bond functionalization

5.2.1 Cyclization C H bond functionalization

5.2.2 Non cyclization C H bond functionalization

5.3 Heteroaromatic C H bond functionalization

5.3.1 Arylation of heteroaromatic C H bonds

5.3.2 Alkenylation of oxazoles with bromoalkenes

5.3.3 Amination of heteroaromatic C H bonds

5.4 Conclusion

References

6 lron Catalysis for Hydrosilyaltion

6.1 Introduction

6.2 Hydrosilylation of olefins

6.3 Hydrosilylation of aldehydes and ketones

6.4 Hydrosilylation reduction of amides to amines

6.5 Conclusion

References

7 Stereoselective Formation Chiral Heterocyclic Compounds via Cross Dehydrogenative Coupling Reactions of sp3C-H Bonds

7.1 Introduction

7.2 Copper catalyzed synthesis of tetrahydroisoquinoline derivatives

7.3 Organocatalytic synthesis of xanthene and indole derivatives

7.4 Copper catalyzed synthesis of indole derivatives

7.5 Conclusion

References

8 Synthesis of Cyclpentadienyl Titanium or Zirconium Complexes and Application in Hydrogenation of Olefins

8.1 Synthesis of cyclopentadienyl zirconium complexes

8.2 Synthesis of cyclopentadienyl titanium complexes

8.3 Hydrogenation of olefins using titanocenes

References

《Metal-Promoted Organic Reactions》重点介绍金属促进的有机化学反应，全书由八部分组成，内容包括过渡金属催化的通过SP2C-H官能化合成杂环化合物、过渡金属催化的通过SP3C-H官能化合成杂环化合物、铜催化的芳烃C-H官能化、芳烃C-H转化为C-N键、唑类化合物的胺化、杂环化合物不对称官能化、烯烃醛酮和酰胺氢硅化、茂钛族络合物的合成及催化烯烃氢化等，对反应机理进行了详细介绍。反映了相关领域的现状并进行了展望。
　　《Metal-Promoted Organic Reactions》可供从事有机化学、药物化学的科研人员参考，也可作为高等院校高年级本科生及研究生的教学参考书。

适读人群 ：有机化学、有机合成领域研究与从业人员，高等院校药物合成、有机化学等高年级本科生、研究生，研究单位研究人员。

　　《Metal-Promoted Organic Reactions》作者自20世纪80年代至今一直从事有机化学的研究工作，本图书中特别对碳-氢活化进行了一些解读，同时介绍了一些关于茂金属化合物的合成及其应用的内容，它是金属有机化学的重要组成部分，这些内容都包含了作者本人的独到见解，具参考意义。