生物纳米电子学

Contents

1 Fundamentals on Bionanotechnologies 1

1.1 TransportPhenomenaattheNanoscale 1

1.2 Nanotechnologiesfor BionanoelectronicDevices 18

1.2.1 Deposition Techniques for BionanoelectronicDevices 18

1.2.2 Nanolithography 20

1.2.3 Nanomaterials 27

1.3 Conduction Properties of BiologicalMaterials 35

1.4 Micro.uidics and Nano.uidics 46

References 54

2 Sensing of Biomolecules 57

2.1 Nanotransistors Based on Nanotubes, Nanowires, andGrapheneforBiosensing 57

2.2 DNA Detection and SequencingUsing Nanopores 73

2.3 MEMS/NEMS Biodetection 80

2.4 Plasmonics Biodetection 87

2.5 NanoelectronicNoses and Various Disease Detection 98

References 102

3 Imaging and Manipulation of Biomolecules 107

3.1 Bioapplications of Atomic Force Microscopy 107

3.2 Bioapplicationsof Scanning TunnelingMicroscopy 114

3.3 ManipulationofBiologicalMaterials 117

References 123

4 Nanomedicine 127

4.1 Drug Deliveryand Healing Based on Nanomaterials 127

4.2 Biochips—DNAArraysandOtherChipsforDiagnosis 144

4.3 Arti.cial Tissues and Organs 146

References 148

5 Biomolecular Architecture for Nanotechnology 151

5.1 DNA-BasedMolecularArchitectures 152

5.2 Self-Assembled DNA Nanowires 155

5.3 Two-and Three-DimensionalBioarchitectures as Scaffolds 159

5.4 NonperiodicBiologicalScaffoldsforInorganicStructures 165

5.5 InorganicScaffolds for Biomolecules 169

References 170

6 Biomolecular Machines 173

6.1 BiologicalActuatorsandSwitches 174

6.2 Biological Walkers 180

6.3 Biological Motors 183

References 187

7 Biomolecular Computing 189

7.1 Principles of Biomolecular Computing 189

7.2 Boolean BiomolecularComputing 192

7.3 Self-AssemblyBiomolecularComputing 198

7.4 Biomolecular Logical Deductions 200

7.5 Biomolecular Memory Devices 201

7.6 Logical Drug Delivery and In Vivo Computation 203

References 205

8 Bioinspired Devices 207

8.1 Bioinspired Materials 208

8.2 Bioinspired Devices 215

8.3 Bioinspired TechnologicalProcesses 222

8.4 Devices Mimicking Biological Organs/Functionalities 224

References 229

9 Nano-Bio Integration 233

9.1 Nano-bioMaterials for Electronics and Optoelectronics 233

9.2 Nano-bioMechanical Devices 236

9.3 Nanobioelectronicsand Optoelectronics 239

References 246

Index 249

About the Authors 253

生物纳米电子学主要阐述纳米电子学在生物及医学领域的应用。介绍纳米器件在生物结构、分子马达、分子泵、分子纳米制动器及电子生物器件中的应用，包括DNA的检测及测序，各种疾病的早期检查和纳米医学等内容。此外，《生物纳米电子学》还介绍了生物模拟和生物激发的电子学，扫描探针技术在生物样品检测方面的应用，还阐述了将生物分子作为纳米器件以及潜在的计算元件的构筑单元。