生物医学纳米技术 : 方法与操作

Contents

Preface . v

Contributors ix

1 Biomedical Nanotechnology 1

Sarah J. Hurst

PART I USING NANOMATERIALS IN SENSING, IMAGING, AND THERAPEUTICS

2 Multiplexed Detection of Oligonucleotides with Biobarcoded Gold

Nanoparticle Probes 17

Jae-Seung Lee

3 Molecular Detection of Biomarkers and Cells Using Magnetic

Nanoparticles and Diagnostic Magnetic Resonance 33

Jered B. Haun, Tae-Jong Yoon, Hakho Lee, and Ralph Weissleder

4 Real-Time Quantum Dot Tracking of Single Proteins . 51

Jerry C. Chang and Sandra J. Rosenthal

5 Titanium Dioxide Nanoparticles in Advanced

Imaging and Nanotherapeutics 63

Tijana Rajh, Nada M. Dimitrijevic, and Elena A. Rozhkova

6 Surface Modification and Biomolecule Immobilization

on Polymer Spheres for Biosensing Applications 77

Chris R. Taitt, Lisa C. Shriver-Lake, George P. Anderson,

and Frances S. Ligler

7 Multivalent Conjugation of Peptides, Proteins, and DNA

to Semiconductor Quantum Dots . 95

Duane E. Prasuhn, Kimihiro Susumu, and Igor L. Medintz

8 A Single SnO2 Nanowire-Based Microelectrode 111

Jun Zhou, Yaguang Wei, Qin Kuang, and Zhong Lin Wang

9 Biosensing Using Nanoelectromechanical Systems 119

Ashish Yeri and Di Gao

10 Nano “Fly Paper” Technology for the Capture of Circulating Tumor Cells 141

Shutao Wang, Gwen E. Owens, and Hsian-Rong Tseng

11 Polymeric Nanoparticles for Photodynamic Therapy 151

Yong-Eun Koo Lee and Raoul Kopelman

12 Hydrogel Templates for the Fabrication of Homogeneous

Polymer Microparticles 179

Ghanashyam Acharya, Matthew McDermott, Soo Jung Shin,

Haesun Park, and Kinam Park

13 Antibacterial Application of Engineered Bacteriophage

Nanomedicines: Antibody-Targeted, Chloramphenicol Prodrug

Loaded Bacteriophages for Inhibiting the Growth

of Staphylococcus aureus Bacteria 187

Lilach Vaks and Itai Benhar

14 Viruses as Nanomaterials for Drug Delivery 207

Dustin Lockney, Stefan Franzen, and Steven Lommel

15 Applications of Carbon Nanotubes in Biomedical Studies . 223

Hongwei Liao, Bhavna Paratala, Balaji Sitharaman,

and Yuhuang Wang

16 Electrospun Nanofibrous Scaffolds for Engineering Soft Connective Tissues 243

Roshan James, Udaya S. Toti, Cato T. Laurencin,

and Sangamesh G. Kumbar

17 Peptide Amphiphiles and Porous Biodegradable Scaffolds

for Tissue Regeneration in the Brain and Spinal Cord . 259

Rutledge G. Ellis-Behnke and Gerald E. Schneider

18 Computational Simulations of the Interaction of Lipid Membranes

with DNA-Functionalized Gold Nanoparticles 283

One-Sun Lee and George C. Schatz

PART II TRANSLATING NANOSCIENCE AND TECHNOLOGY

FROM THE LAB TO THE CLINIC

19 Cytotoxic Assessment of Carbon Nanotube Interaction

with Cell Cultures . 299

Hanene Ali-Boucetta, Khuloud T. Al-Jamal,

and Kostas Kostarelos

20 Nanoparticle Toxicology: Measurements of Pulmonary

Hazard Effects Following Exposures to Nanoparticles . 313

Christie M. Sayes, Kenneth L. Reed, and David B. Warheit

21 Nanoparticle Therapeutics: FDA Approval, Clinical Trials,

Regulatory Pathways, and Case Study . 325

Aaron C. Eifler and C. Shad Thaxton

22 Legislating the Laboratory? Promotion and Precaution

in a Nanomaterials Company . 339

Robin Phelps and Erik Fisher

23 Navigating the Patent Landscapes for Nanotechnology: English

Gardens or Tangled Grounds? 359

Douglas J. Sylvester and Diana M. Bowman

24 Scientific Entrepreneurship in the Materials and Life Science Industries 379

Jose Amado Dinglasan, Darren J. Anderson, and Keith Thomas

25 Applying the Marketing Mix (5 Ps) to Bionanotechnology 393

Michael S. Tomczyk

26 Managing the “Known Unknowns”: Theranostic Cancer

Nanomedicine and Informed Consent 413

Fabrice Jotterand and Archie A. Alexander

Index 431